Grape Seed Extract
- Latin Name: Vitis vinifera
- Common Name: Grape Seed Extract (GSE)
- Family: Vitaceae
- Source: Derived from wine grape seeds worldwide

What is Grape Seed Extract?
Grape seed extract represents a sophisticated botanical concentrate derived from the seeds of wine grapes, particularly after the wine-making process. These seeds contain some of nature's most concentrated sources of proanthocyanidins and polyphenols.
The extraction process involves carefully separating these beneficial compounds from the seeds using specialized techniques that preserve their natural properties.
Grape Seed Extract Benefits
Grape seed extract benefits include several potential wellness advantages:
What makes grape seed extract particularly notable is its rich profile of oligomeric proanthocyanidin complexes (OPCs), which are naturally occurring plant compounds. These compounds demonstrate remarkable stability and bioavailability, making them effective when taken as supplements.
PureHealth Research Products with Grape Seed Extract
Grape Seed Extract Dosage
Age Group / Need
Recommended Daily Amount
Adults (18-64)
100-300mg with meals
Seniors (65+)
Begin at 50mg, increase slowly up to 300mg as needed
Active Adults
200-400mg, split before and after exercise
Higher Body Weight
Up to 400mg, divided throughout the day
Maximum Daily Limit
900mg
Not Recommended
Children, expecting or nursing mothers
Age Group / Need | Recommended Daily Amount |
---|---|
Adults (18-64) | 100-300mg with meals |
Seniors (65+) | Begin at 50mg, increase slowly up to 300mg as needed |
Active Adults | 200-400mg, split before and after exercise |
Higher Body Weight | Up to 400mg, divided throughout the day |
Maximum Daily Limit | 900mg |
Not Recommended | Children, expecting or nursing mothers |
For your comfort, consider dividing your daily amount into two portions - one with breakfast and one with dinner. This gentle approach often works best for most of us.
Interactions with Other Ingredients
Grape seed extract works synergistically with several nutrients, enhancing vitamin C's antioxidant effects. However, it requires careful timing with iron supplements as it may affect absorption.
Blood-thinning medications warrant special attention due to its circulatory effects, and antihypertensive medicines may require monitoring as grape seed extract might influence blood pressure levels.
Grape Seed Extract Side Effects
While grape seed extract is generally gentle on your system, it's helpful to know what to expect when you begin taking it. You might notice some changes in your circulation - perhaps a slight warming sensation or tingling in your hands and feet.
Your digestion may need a few days to adjus. Some people notice mild changes in their energy levels at first, but this typically balances out within a week or two. Starting with a smaller amount and taking it with food helps ensure your comfort. If you notice anything unusual, simply reduce your serving size or check with your healthcare provider.
Is grape seed extract an antioxidant?
Yes, grape seed extract contains powerful antioxidant compounds, particularly proanthocyanidins, which support cellular protection.
How much grape seed extract to lower estrogen?
While individual needs vary, typical doses range from 100-300mg daily. Working with a wellness professional can help determine personal needs.
What is the best time to take grape seed extract?
Many people find taking it with meals helps optimize absorption. Morning or evening administration works well, depending on your routine.